Endocrine Regulation of the Growth Plate
نویسندگان
چکیده
منابع مشابه
Endocrine regulation of the growth plate.
Longitudinal bone growth occurs at the growth plate by endochondral ossification. Within the growth plate, chondrocyte proliferation, hypertrophy, and cartilage matrix secretion result in chondrogenesis. The newly formed cartilage is invaded by blood vessels and bone cells that remodel the newly formed cartilage into bone tissue. This process of longitudinal bone growth is governed by a complex...
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Longitudinal growth is primarily influenced by the GH-IGF-I axis, which is a mixed endocrine-paracrine-autocrine system. Further, classical hormones such as thyroxine, glucocorticosteroids and sex steroids play a role, as well as primarily paracrine systems. In the GH-IGF-I axis, seven disorders can be differentiated: (1) GH deficiency; (2) GHR defects; (3) defects in the GH signal transduction...
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ژورنال
عنوان ژورنال: Hormone Research in Paediatrics
سال: 2005
ISSN: 1663-2818,1663-2826
DOI: 10.1159/000088791